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L-Aspartic acid

CAS No. 56-84-8

L-Aspartic acid ( Aspartic acid | Aspatofort | EC 200-291-6 )

产品货号. M18824 CAS No. 56-84-8

天冬氨酸是人体的非必需氨基酸,天冬氨酸整体带负电荷,在其他氨基酸的合成以及柠檬酸和尿素循环中发挥着重要作用。

纯度: >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
规格 价格/人民币 库存 数量
500MG ¥332 有现货
1G ¥389 有现货

生物学信息

  • 产品名称
    L-Aspartic acid
  • 注意事项
    本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
  • 产品简述
    天冬氨酸是人体的非必需氨基酸,天冬氨酸整体带负电荷,在其他氨基酸的合成以及柠檬酸和尿素循环中发挥着重要作用。
  • 产品描述
    Aspartic Acid is a non-essential amino acid in humans, Aspartic Acid has an overall negative charge and plays an important role in the synthesis of other amino acids and in the citric acid and urea cycles. Asparagine, arginine, lysine, methionine, isoleucine, and some nucleotides are synthesized from aspartic acid. Aspartic acid also serves as a neurotransmitter.(In Vitro):L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu.
  • 体外实验
    ——
  • 体内实验
    L-Aspartic acid is shown to be a suitable prodrug for colon-specific drug deliverly. L-[3H]Asp remaining in the brain at 5 min is increased by 206 and 178% by preadministration of 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, whereas 100 mM D-Asp does not affect L-[3H]Asp efflux transport. That value for L-[3H]Glu at 20 min is increased by 145 and 156% by coadministration with 100 mM L-Aspartic acid and 100 mM L-Glu, respectively, but not by D-Asp. It is interesting that the apparent efflux rate of L-Aspartic acid across the BBB is sevenfold faster than that of L-Glu.
  • 同义词
    Aspartic acid | Aspatofort | EC 200-291-6
  • 通路
    Others
  • 靶点
    Other Targets
  • 受体
    Others
  • 研究领域
    ——
  • 适应症
    ——

化学信息

  • CAS Number
    56-84-8
  • 分子量
    133.1
  • 分子式
    C4H7NO4
  • 纯度
    >98% (HPLC)
  • 溶解度
    H2O : 8.33 mg/mL 62.58 mM
  • SMILES
    C(C(C(=O)O)N)C(=O)O
  • 化学全称
    L-aspartic acid

运输与储存

  • 储存条件
    (-20℃)
  • 运输条件
    With Ice Pack
  • 稳定性
    ≥ 2 years

参考文献

1.Leopold CS, et al. In vivo pharmacokinetic study for the assessment of poly(L-aspartic acid) as a drug carrier for colon-specific drug delivery. J Pharmacokinet Biopharm. 1995 Aug;23(4):397-406.
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